Sparc^tm1Anjm
Targeted Allele Detail

Summary

• Symbol: Sparc^tm1Anjm
• Name: secreted acidic cysteine rich glycoprotein; targeted mutation 1, Andrew N J McKenzie
• MGI ID: MGI:4421677
• Gene: Sparc Location: Chr11:55284985-55310906 bp, - strand Genetic Position: Chr11, 33.04 cM, cytoband B1
• Alliance: Sparc^tm1Anjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155870
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lox P site and neo cassette were inserted between exons 5 and 7, eliminating exon 6, as well as inserting stop codons into all three frames upstream of the neo. (J:155870)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sparc Mutation: 76 strains or lines available

References

• Original: J:155870 Barlow JL, et al., A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010 Jan;16(1):59-66
• All: 1 reference(s)