Del(11Nmur2-Sparc)2Anjm
Targeted Allele Detail

Summary

• Symbol: Del(11Nmur2-Sparc)2Anjm
• Name: deletion, Chr 11, Andrew N J McKenzie
• MGI ID: MGI:4421680
• Synonyms: Del(11Nmu2r-Sparc)2Anjm
• Gene: Del(11Nmur2-Sparc)2Anjm Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155870
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(11Nmur2-Sparc)2Anjm involves 11 genes/genome features (Gm32012, Sparc, Atox1 ...) View all
• Mutation details: This deletion was created by cre mediated recombination of loxP sites within Nmur2 (created by random insertion vector of loxP-Puro cassette) and Sparc (created by eliminating exon 6 and replacing it with a Neo-LoxP as well as inserting stop codons in all three reading-frames). The deletion spans a 0.5 Mb Mb interval between Nmur2 and Sparc and includes Glra1, G3bp1 and Atox1. (J:155870)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(11Nmur2-Sparc)2Anjm Mutation: 0 strains or lines available

References

• Original: J:155870 Barlow JL, et al., A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010 Jan;16(1):59-66
• All: 1 reference(s)