Csf1r^tm1Anjm
Targeted Allele Detail

Summary

• Symbol: Csf1r^tm1Anjm
• Name: colony stimulating factor 1 receptor; targeted mutation 1, Andrew N J McKenzie
• MGI ID: MGI:4421685
• Gene: Csf1r Location: Chr18:61238644-61264211 bp, + strand Genetic Position: Chr18, 34.41 cM, cytoband D
• Alliance: Csf1r^tm1Anjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155870
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The MICER clone MHPP344i11 containing exon 3-9, loxP and a puro cassette was used to target the gene in ES cells that carried Ars1 ^tm1Anjm. Clones where the two mutations are in cis were selected to generate mice. (J:155870)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Arsi^tm1Anjm/Arsi^+ Csf1r^tm1Anjm/Csf1r^+ Lmo2^tm2(cre)Thr/Lmo2^+	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	cn1
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hematopoietic system	N
hematopoietic system phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csf1r Mutation: 67 strains or lines available

References

• Original: J:155870 Barlow JL, et al., A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010 Jan;16(1):59-66
• All: 1 reference(s)