Agr2^tm1.1Lpkn
Targeted Allele Detail

Summary

• Symbol: Agr2^tm1.1Lpkn
• Name: anterior gradient 2; targeted mutation 1.1, Steven M Lipkin
• MGI ID: MGI:4421687
• Synonyms: Agr2^Flox
• Gene: Agr2 Location: Chr12:36042924-36054080 bp, + strand Genetic Position: Chr12, 16.18 cM
• Alliance: Agr2^tm1.1Lpkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156704
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 4. Cre mediated recombination removed the neo cassette leaving exons 2 through 4 floxed. (J:156704)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agr2 Mutation: 34 strains or lines available

References

• Original: J:156704 Zhao F, et al., Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev Biol. 2010 Feb 15;338(2):270-9
• All: 2 reference(s)