Cd74^tm1Anjm
Targeted Allele Detail

Summary

• Symbol: Cd74^tm1Anjm
• Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); targeted mutation 1, Andrew N J McKenzie
• MGI ID: MGI:4421688
• Gene: Cd74 Location: Chr18:60936921-60945724 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Cd74^tm1Anjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155870
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette with loxP sites was inserted into intron 3 of ES cells containing 2010002N04Rik^tm1Anjm Clones where the two mutations are in cis were selected to generate mice. (J:155870)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd74 Mutation: 36 strains or lines available

References

• Original: J:155870 Barlow JL, et al., A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010 Jan;16(1):59-66
• All: 1 reference(s)