Grn^tm1.1Aidi
Targeted Allele Detail

Summary

• Symbol: Grn^tm1.1Aidi
• Name: granulin; targeted mutation 1.1, Aihao Ding
• MGI ID: MGI:4421705
• Gene: Grn Location: Chr11:102321333-102327635 bp, + strand Genetic Position: Chr11, 66.29 cM
• Alliance: Grn^tm1.1Aidi page

Exaggerated tissue inflammation in Grn^tm1.1Aidi/Grn^tm1.1Aidi mice after infection with L. monocytogenes

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156824
• Parent Cell Line: C2J (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre mediated recombination removed exons 1 through 4. The absence of protein expression was confirmed by western blot analysis on bone marrow-derived macrophages. (J:156824)

Generation of the Grn^tm1Aidi and Grn^tm1.1Aidi alleles

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grn Mutation: 48 strains or lines available

References

• Original: J:156824 Yin F, et al., Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. J Exp Med. 2010 Jan 18;207(1):117-28, S1-4
• All: 42 reference(s)