Pgk2^tm1Dao
Targeted Allele Detail

Summary

• Symbol: Pgk2^tm1Dao
• Name: phosphoglycerate kinase 2; targeted mutation 1, Deborah A O'Brien
• MGI ID: MGI:4421784
• Gene: Pgk2 Location: Chr17:40517909-40519500 bp, - strand Genetic Position: Chr17, 19.44 cM
• Alliance: Pgk2^tm1Dao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156646
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the coding region was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on sperm and testis extracts. (J:156646)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pgk2 Mutation: 28 strains or lines available

References

• Original: J:156646 Danshina PV, et al., Phosphoglycerate kinase 2 (PGK2) is essential for sperm function and male fertility in mice. Biol Reprod. 2010 Jan;82(1):136-45
• All: 2 reference(s)