Sgk3^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Sgk3^m1Btlr
• Name: serum/glucocorticoid regulated kinase 3; mutation 1, Bruce Beutler
• MGI ID: MGI:4421790
• Synonyms: woolly
• Gene: Sgk3 Location: Chr1:9868332-9971070 bp, + strand Genetic Position: Chr1, 2.08 cM
• Alliance: Sgk3^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The woolly mutation comprises a T to C transition at nucleotide position 87975 of the genomic DNA sequence (Genbank genomic region NC_000067 for linear genomic DNA sequence of Sgk3), in the 16th of the gene's 19 exons. The mutated base corresponds to nucleotide 1382 of transcript variant 1, Genbank record: NM_133220. The mutation is predicted to result in replacement of the cysteine at amino acid position 246, in the kinase domain, by arginine (C246R). (J:156584)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sgk3 Mutation: 30 strains or lines available

References

• Original: J:156584 Siggs O, et al., Woolly is an allele of Sgk3 and displays a curly coat. MGI Direct Data Submission. 2010
• All: 1 reference(s)