Klf5^tm2.1Rng
Targeted Allele Detail

Summary

• Symbol: Klf5^tm2.1Rng
• Name: Kruppel-like transcription factor 5; targeted mutation 2.1, Ryozo Nagai
• MGI ID: MGI:4421792
• Synonyms: Klf5^fl
• Gene: Klf5 Location: Chr14:99536127-99550848 bp, + strand Genetic Position: Chr14, 49.43 cM, cytoband E2.1
• Alliance: Klf5^tm2.1Rng page

Fibroblast-specific deletion of Klf5 attenuates cardiac hypertrophy and fibrosis after TAC in Klf5^tm2.1Rng/Klf5^tm2.1Rng Tg(Postn-cre)1Sjc mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156696
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2 and a neo cassette flanked by loxP and frt sites was inserted downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:156696)

Generation of the Klf5^tm2.1Rng allele

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf5 Mutation: 37 strains or lines available

References

• Original: J:156696 Takeda N, et al., Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest. 2010 Jan;120(1):254-65
• All: 15 reference(s)