Phlpp1^tm1.1Saco
Targeted Allele Detail

Summary

• Symbol: Phlpp1^tm1.1Saco
• Name: PH domain and leucine rich repeat protein phosphatase 1; targeted mutation 1.1, Paolo Sassone-Corsi
• MGI ID: MGI:4421807
• Gene: Phlpp1 Location: Chr1:106099599-106321975 bp, + strand Genetic Position: Chr1, 49.76 cM
• Alliance: Phlpp1^tm1.1Saco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156530
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 4 was floxed and an frt flanked neo cassette was inserted in intron 4 via homologous recombination. Cre mediated recombination then removed exon 4. RT-PCR and western blot analysis confirmed the absence of RNA and protein expression in brains from homozygous mice. (J:156530)

Generation of the Phlpp1^tm1Saco and Phlpp1^tm1.1Saco alleles

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phlpp1 Mutation: 52 strains or lines available

References

• Original: J:156530 Masubuchi S, et al., Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1642-7
• All: 20 reference(s)