Del(16Tssk1-Tssk2)1Agr
Targeted Allele Detail

Summary

• Symbol: Del(16Tssk1-Tssk2)1Agr
• Name: deletion, Chr 16, J Anton Grootegoed 1
• MGI ID: MGI:4421830
• Synonyms: Del1Agr, Tssk1/2^-, Tssk1/Tssk2^tm1.1Agr
• Gene: Del(16Tssk1-Tssk2)1Agr Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156758
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(16Tssk1-Tssk2)1Agr involves 2 genes/genome features (Tssk1, Tssk2) View all
• Mutation details: Cre-mediated recombination between Tssk1^tm1Agr and Tssk2^tm1Agr removed both open reading frames and the 3.06 kb intergenic region. The absence of protein expression was confirmed by western blot analysis of elongating spermatids. (J:156758)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(16Tssk1-Tssk2)1Agr Mutation: 0 strains or lines available

References

• Original: J:156758 Shang P, et al., Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases. J Cell Sci. 2010 Feb 1;123(Pt 3):331-9
• All: 1 reference(s)