Kdr^tm1Wag
Targeted Allele Detail

Summary

• Symbol: Kdr^tm1Wag
• Name: kinase insert domain protein receptor; targeted mutation 1, Erwin F Wagner
• MGI ID: MGI:4422101
• Synonyms: Flk1^lox, Flk1^loxP, Vegfr2^lox
• Gene: Kdr Location: Chr5:76093487-76139118 bp, - strand Genetic Position: Chr5, 40.23 cM
• Alliance: Kdr^tm1Wag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86207
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an frt floxed neo cassette was inserted downstream of exon 1. (J:86207, J:156986)

Expression

In Mice Carrying this Mutation:	42 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdr Mutation: 74 strains or lines available

References

• Original: J:86207 Haigh JJ, et al., Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol. 2003 Oct 15;262(2):225-41
• All: 33 reference(s)