Stk3^tm1.1Yy
Targeted Allele Detail

Summary

• Symbol: Stk3^tm1.1Yy
• Name: serine/threonine kinase 3; targeted mutation 1.1, Yingzi Yang
• MGI ID: MGI:4422170
• Synonyms: Mst2^delta
• Gene: Stk3 Location: Chr15:34875645-35155990 bp, - strand Genetic Position: Chr15, 14.34 cM, cytoband B3.3
• Alliance: Stk3^tm1.1Yy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156541
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5 and an frt flanked neo cassette and second loxP site were inserted downstream of exon 6. Cre mediated recombination then removed exons 5 and 6 (encoding the kinase domain) and the neo cassette. Western blot analysis confirmed the absence of protein expression in homozygous embryos. (J:156541)

Tumor Data

List all tumor models in MMHCdb carrying Stk3^tm1.1Yy

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk3 Mutation: 49 strains or lines available

References

• Original: J:156541 Song H, et al., Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1431-6
• All: 3 reference(s)