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Tg(Htt-ATXN3*148Q)3746Thsc
Transgene Detail
Summary
Symbol: Tg(Htt-ATXN3*148Q)3746Thsc
Name: transgene insertion 3746, Thorsten Schmidt
MGI ID: MGI:4429385
Synonyms: HDPromMJD148
Transgene: Tg(Htt-ATXN3*148Q)3746Thsc  Location: unknown  
Alliance: Tg(Htt-ATXN3*148Q)3746Thsc page
Transgene
origin
Strain of Origin:  C57BL/6N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Htt-ATXN3*148Q)3746Thsc expresses 1 gene
 
Mutation detailsThe rat promoter drives whole brain expression of the human cDNA for isoform C. The polyglutamine trinucleotide CAG repeat was expanded to 148 copies (148Q). One line, 3746, was created. (J:156912)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:156912 Boy J, et al., A transgenic mouse model of spinocerebellar ataxia type 3 resembling late disease onset and gender-specific instability of CAG repeats. Neurobiol Dis. 2010 Feb;37(2):284-293
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory