Ctnnb1tm4.1Wbm
Targeted Allele Detail
|
Symbol: |
Ctnnb1tm4.1Wbm |
Name: |
catenin beta 1; targeted mutation 4.1, Walter Birchmeier |
MGI ID: |
MGI:4429437 |
Synonyms: |
Ctnnb1- |
Gene: |
Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
|
Alliance: |
Ctnnb1tm4.1Wbm page
|
|
Anterior head defects during embryonic development in ApcMin/Apctm1Tno embryos and rescue of head defects by Ctnnb1tm4.1Wbm/Ctnnb1+
Show the 2 phenotype image(s) involving this allele.
|
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:156864
|
Parent Cell Line: |
E14 (ES Cell)
|
Strain of Origin: |
129P2/OlaHsd
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A loxP site was inserted into the second intron and a loxP-flanked neomycin selection cassette was inserted into the sixth intron. The neomycin cassette was removed by transient expression of Cre recombinase in ES cells prior to the production of chimeric mice, leaving two loxP sites that flank exons 3-6 in the final allele. Exons 3-6 were excised by Cre mediated recombination.
(J:69463, J:156864)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Ctnnb1 Mutation: |
48 strains or lines available
|
|
Original: |
J:156864 Buchert M, et al., Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet. 2010 Jan;6(1):e1000816 |
All: |
5 reference(s) |
|