Ctnnb1^tm4.1Wbm
Targeted Allele Detail

Summary

• Symbol: Ctnnb1^tm4.1Wbm
• Name: catenin beta 1; targeted mutation 4.1, Walter Birchmeier
• MGI ID: MGI:4429437
• Synonyms: Ctnnb1^-
• Gene: Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
• Alliance: Ctnnb1^tm4.1Wbm page

Anterior head defects during embryonic development in Apc^Min/Apc^tm1Tno embryos and rescue of head defects by Ctnnb1^tm4.1Wbm/Ctnnb1⁺

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156864
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into the second intron and a loxP-flanked neomycin selection cassette was inserted into the sixth intron. The neomycin cassette was removed by transient expression of Cre recombinase in ES cells prior to the production of chimeric mice, leaving two loxP sites that flank exons 3-6 in the final allele. Exons 3-6 were excised by Cre mediated recombination. (J:69463, J:156864)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnb1 Mutation: 49 strains or lines available

References

• Original: J:156864 Buchert M, et al., Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet. 2010 Jan;6(1):e1000816
• All: 5 reference(s)