Fgfr4^tm1Axul
Targeted Allele Detail

Summary

• Symbol: Fgfr4^tm1Axul
• Name: fibroblast growth factor receptor 4; targeted mutation 1, Axel Ullrich
• MGI ID: MGI:4429449
• Synonyms: FGFR4Arg385, FGFR4-R385
• Gene: Fgfr4 Location: Chr13:55300631-55316572 bp, + strand Genetic Position: Chr13, 29.8 cM
• Alliance: Fgfr4^tm1Axul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156750
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: A loxP flanked Neo cassette was inserted into intron 10 and a single nucleotide substitution that resulted in an amino acid substitution of Glycine 385 to Arginine (G385R) was inserted into exon 8 by homologous recombination. (J:156750)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Fgfr4^tm1Axul

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr4 Mutation: 42 strains or lines available

References

• Original: J:156750 Seitzer N, et al., A single nucleotide change in the mouse genome accelerates breast cancer progression. Cancer Res. 2010 Jan 15;70(2):802-12
• All: 9 reference(s)