Tg(Ckm-Ppard)LEDpk
Transgene Detail

Summary

• Symbol: Tg(Ckm-Ppard)LEDpk
• Name: transgene insertion LE, Daniel P Kelly
• MGI ID: MGI:4429472
• Transgene: Tg(Ckm-Ppard)LEDpk Location: unknown
• Alliance: Tg(Ckm-Ppard)LEDpk page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-Ppard)LEDpk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppard (MGI:101884)

• Mutation details: The mouse Ckm (creatine kinase, muscle) promoter drives expression of mouse Ppard (peroxisome proliferator activated receptor delta) cDNA carrying a C-terminal FLAG tag. High, medium, and low expressor lines were created (HE, ME, and LE). This is a low expressor line (LE). (J:129848)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Ppara^tm1Gonz/Ppara^tm1Gonz Tg(Ckm-Ppard)LEDpk/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA

Phenotypes:

Affected Systems	cx1
show or hide all annotated terms
homeostasis/metabolism	√
abnormal glucose tolerance	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:129848 Finck BN, et al., A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metab. 2005 Feb;1(2):133-44
• All: 2 reference(s)