Tg(Myh6-Ppard)HEDpk
Transgene Detail

Summary

• Symbol: Tg(Myh6-Ppard)HEDpk
• Name: transgene insertion HE, Daniel P Kelly
• MGI ID: MGI:4429481
• Synonyms: MHC-PPARbeta
• Transgene: Tg(Myh6-Ppard)HEDpk Location: unknown
• Alliance: Tg(Myh6-Ppard)HEDpk page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Ppard)HEDpk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppard (MGI:101884)

• Mutation details: A mouse Ppard cDNA was cloned downstream of the mouse Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter. Three lines were created with low (20-fold over levels of the corresponding nuclear receptor), medium (50-fold), and high (100-fold) expression levels (LE, ME, and HE). This is a high expression line. (J:130750)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:130750 Burkart EM, et al., Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. J Clin Invest. 2007 Dec;117(12):3930-9
• All: 1 reference(s)