Cux2^tm1.1Nieto
Targeted Allele Detail

Summary

• Symbol: Cux2^tm1.1Nieto
• Name: cut-like homeobox 2; targeted mutation 1.1, Marta Nieto
• MGI ID: MGI:4429541
• Gene: Cux2 Location: Chr5:121996025-122188522 bp, - strand Genetic Position: Chr5, 62.02 cM
• Alliance: Cux2^tm1.1Nieto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156578
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 22 and 23 were floxed to create a premature stop at the C-teminus in the presence of cre recombinase. A Neo cassette and a 3rd loxP site were inserted within intron 23. Exons 22, 23 and the neo cassette were removed by cre-mediated recombination. Absence of protein in brain was confirmed by western blot and immunohistochemistry. (J:156578)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cux2 Mutation: 43 strains or lines available

References

• Original: J:156578 Cubelos B, et al., Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone. Cereb Cortex. 2008 Aug;18(8):1758-70
• All: 5 reference(s)