Slc26a7^tm1Sole
Targeted Allele Detail

Summary

• Symbol: Slc26a7^tm1Sole
• Name: solute carrier family 26, member 7; targeted mutation 1, Manoocher Soleimani
• MGI ID: MGI:4429559
• Gene: Slc26a7 Location: Chr4:14502430-14621805 bp, - strand Genetic Position: Chr4, 6.24 cM
• Alliance: Slc26a7^tm1Sole page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156969
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 3 and 4 were replaced by a neomycin selection cassette. These exons encode 168 amino acids. Northern blot analysis confirmed the absence of mRNA and the absence of protein was established immunologically. (J:156969)

Generation of the Slc26a7^tm1Sole allele

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc26a7 Mutation: 50 strains or lines available

References

• Original: J:156969 Xu J, et al., Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. J Biol Chem. 2009 Oct 23;284(43):29470-9
• All: 6 reference(s)