Dnase1l1^tm1Dkfz
Targeted Allele Detail

Summary

• Symbol: Dnase1l1^tm1Dkfz
• Name: deoxyribonuclease 1-like 1; targeted mutation 1, German Cancer Research Center
• MGI ID: MGI:4430191
• Gene: Dnase1l1 Location: ChrX:73316823-73325939 bp, - strand Genetic Position: ChrX, 37.94 cM
• Alliance: Dnase1l1^tm1Dkfz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156989
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette has replaced a segment of the gene including exons 3-5; exon 3 contains the ATG translation initiation codon. If splicing occurs between exons 2 and 6, translation from the only in-frame ATG would yield a 60-amino acid (aa) peptide (the full length protein contains 302 aa) that lacks the activity domain. (J:156989)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnase1l1 Mutation: 65 strains or lines available

References

• Original: J:156989 Krebs I, et al., Targeted mutation of Dnase1l1. MGI Direct Data Submission. 2010
• All: 2 reference(s)