Foxl2^tm2.1Tre
Targeted Allele Detail

Summary

• Symbol: Foxl2^tm2.1Tre
• Name: forkhead box L2; targeted mutation 2.1, Mathias Treier
• MGI ID: MGI:4430192
• Synonyms: Foxl2^f, Foxl2^flox
• Gene: Foxl2 Location: Chr9:98837495-98840601 bp, + strand Genetic Position: Chr9, 51.41 cM, cytoband E4
• Alliance: Foxl2^tm2.1Tre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157008
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was used to insert loxP sites to flank the single coding exon of the Foxl2 locus by homologous recombination in ES cells. An FRT-flanked neomycin selection cassette introduced during recombination was removed by Flp-mediated recombination, leaving a single residual FRT site. (J:157008)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxl2 Mutation: 15 strains or lines available

References

• Original: J:157008 Uhlenhaut NH, et al., Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell. 2009 Dec 11;139(6):1130-42
• All: 10 reference(s)