Foxl2^tm3Tre
Targeted Allele Detail

Summary

• Symbol: Foxl2^tm3Tre
• Name: forkhead box L2; targeted mutation 3, Mathias Treier
• MGI ID: MGI:4430196
• Synonyms: Foxl2^HAFoxl2
• Gene: Foxl2 Location: Chr9:98837660-98840179 bp, + strand Genetic Position: Chr9, 51.41 cM, cytoband E4
• Alliance: Foxl2^tm3Tre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157008
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Homologous recombination in ES cells was utilized to replace the endognenous Foxl2 sequence with a hemagglutinin (HA)-tagged Foxl2 cDNA and a self-excising neo selection cassette (ACN). The neo cassette was excised in the male germline. (J:157008)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxl2 Mutation: 15 strains or lines available

References

• Original: J:157008 Uhlenhaut NH, et al., Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell. 2009 Dec 11;139(6):1130-42
• All: 1 reference(s)