Foxl2^tm4(cre)Tre
Targeted Allele Detail

Summary

• Symbol: Foxl2^tm4(cre)Tre
• Name: forkhead box L2; targeted mutation 4, Mathias Treier
• MGI ID: MGI:4430207
• Synonyms: Foxl2^Cre
• Gene: Foxl2 Location: Chr9:98837495-98840601 bp, + strand Genetic Position: Chr9, 51.41 cM, cytoband E4
• Alliance: Foxl2^tm4(cre)Tre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157008
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Foxl2^tm4(cre)Tre expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxl2 (MGI:1349428)

• Mutation details: A 1.6 kb fragment encoding cre recombinase followed by the rabbit beta-globin polyadenylation signal was used to generate a targeting vector that replaced the translational start site of Foxl2 with the cre-ATG start codon by homologous recombination. The targeting vector contained a self-excising neo cassette (ACN cassette) and a diphtheria toxin-negative selection cassette (DTA). The ACN cassette was excised during passage through the male germline. (J:157008)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxl2 (mouse) Summary of all recombinase alleles driven by Foxl2. Alliance mouse Foxl2 gene page

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxl2 Mutation: 15 strains or lines available

References

• Original: J:157008 Uhlenhaut NH, et al., Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell. 2009 Dec 11;139(6):1130-42
• All: 2 reference(s)