Fgf8tm1.1Jyhl
Targeted Allele Detail
|
Symbol: |
Fgf8tm1.1Jyhl |
Name: |
fibroblast growth factor 8; targeted mutation 1.1, James Y H Li |
MGI ID: |
MGI:4430251 |
Synonyms: |
Fgf8deltab |
Gene: |
Fgf8 Location: Chr19:45725237-45731354 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband C3-D
|
Alliance: |
Fgf8tm1.1Jyhl page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:135128
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
Not Specified
|
|
Allele Type: |
|
Targeted |
Mutations: |
|
Insertion, Nucleotide substitutions
|
|
|
Mutation details: The intron-exon junction sequence of exon 1D, taaagGTA was changed to catatGTA, abolishing the 5' alternative splice acceptor, while the downstream alternative splice acceptor in exon 1D remained intact. A neo cassette flanked with two loxP sites was placed 400 bp downstream of exon 1D, which was excised later by Cre mediated recombination. RT-PCR analyses revealed that Fgf8b and three minor b-type splice variants were absent in E7.5 mutant embryos.
(J:135128)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Fgf8 Mutation: |
21 strains or lines available
|
|
Original: |
J:135128 Guo Q, et al., Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation. Development. 2007 Jun;134(12):2251-60 |
All: |
2 reference(s) |
|