Gfi1^tm1(cre)Gan
Targeted Allele Detail

Summary

• Symbol: Gfi1^tm1(cre)Gan
• Name: growth factor independent 1 transcription repressor; targeted mutation 1, Lin Gan
• MGI ID: MGI:4430258
• Synonyms: Gfi1^cre, Gfi1-Cre
• Gene: Gfi1 Location: Chr5:107864521-107873671 bp, - strand Genetic Position: Chr5, 52.23 cM
• Alliance: Gfi1^tm1(cre)Gan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156945
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Gfi1^tm1(cre)Gan expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gfi1 (MGI:103170)

• Mutation details: A targeting construct was used to replace the coding sequence of Gfi1 from the translation initiation codon through exon 5 with the coding sequence of cre recombinase. The cre knockin allele was generated in AB1 ES cells. (J:160668)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gfi1 (mouse) Summary of all recombinase alleles driven by Gfi1. Comparative matrix view of recombinase activities Alliance mouse Gfi1 gene page

Expression

In Mice Carrying this Mutation:

56 assay results 3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfi1 Mutation: 31 strains or lines available

References

• Original: J:156945 Hwang CH, et al., Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice. Dev Dyn. 2010 Feb;239(2):505-13
• All: 37 reference(s)