Epha4^tm1.1Bzh
Targeted Allele Detail

Summary

• Symbol: Epha4^tm1.1Bzh
• Name: Eph receptor A4; targeted mutation 1.1, Binhai Zheng
• MGI ID: MGI:4430285
• Synonyms: EphA4^Flox
• Gene: Epha4 Location: Chr1:77343822-77491725 bp, - strand Genetic Position: Chr1, 39.55 cM, cytoband C1-C5
• Alliance: Epha4^tm1.1Bzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157159
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Two loxP sites were inserted flanking exon 3. Preceding the floxed exon 3, a reporter/selection cassette (SA-mCFP-Neo) flanked by two Frt sites, containing a splice acceptor, a membrane-targeted cyan fluorescent protein reporter gene and a neo cassette, was inserted. The targeted allele was bred to an FLP deleter mouse to excise the SA-mCFP-Neo cassette, resulting in a floxed exon 3. (J:157159)

Generation of the Epha4^tm1Bzh, Epha4^tm1.1Bzh and Epha4^tm1.2Bzh alleles

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Epha4 Mutation: 67 strains or lines available

References

• Original: J:157159 Herrmann JE, et al., Generation of an EphA4 conditional allele in mice. Genesis. 2010 Feb;48(2):101-5
• All: 18 reference(s)