Scn10a^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Scn10a^tm1Lex
• Name: sodium channel, voltage-gated, type X, alpha; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:4430300
• Gene: Scn10a Location: Chr9:119437522-119548388 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband distal
• Alliance: Scn10a^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157066
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8-10 were replaced with a IRES-LacZ Neo cassette by homologous recombination. Expression was abolished in the dorsal root ganglia (DRG) and spinal cord as determined by quantitative RT-PCR. (J:157066)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn10a Mutation: 102 strains or lines available

References

• Original: J:157066 Hillsley K, et al., Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Nav1.8 and Nav1.9 null mice. J Physiol. 2006 Oct 1;576(Pt 1):257-67
• All: 2 reference(s)