Irs1^tm2.1Mfw
Targeted Allele Detail

Summary

• Symbol: Irs1^tm2.1Mfw
• Name: insulin receptor substrate 1; targeted mutation 2.1, Morris F White
• MGI ID: MGI:4430350
• Synonyms: IRS1^a
• Gene: Irs1 Location: Chr1:82210822-82269137 bp, - strand Genetic Position: Chr1, 42.0 cM, cytoband C5
• Alliance: Irs1^tm2.1Mfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156999
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A point mutation changing Ser 307 to Ala (S307A) and a floxed Neo cassette placed immediately after the stop codon were inserted by homologous recombination. The neo has been removed by cre-mediated recombination. A residual 66 bp, includes a loxP site, remains in the 3' UTR. (J:156999)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs1 Mutation: 52 strains or lines available

References

• Original: J:156999 Copps KD, et al., Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab. 2010 Jan;11(1):84-92
• All: 3 reference(s)