Stk4^tm1.1Rjo
Targeted Allele Detail

Summary

• Symbol: Stk4^tm1.1Rjo
• Name: serine/threonine kinase 4; targeted mutation 1.1, Randy L Johnson
• MGI ID: MGI:4430536
• Gene: Stk4 Location: Chr2:163916033-163997444 bp, + strand Genetic Position: Chr2, 84.6 cM, cytoband H3
• Alliance: Stk4^tm1.1Rjo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156531
• Parent Cell Line: RJ2.2 (ES Cell)
• Strain of Origin: (C57BL/6Brd-Tyr^c-Brd x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 4 and 5 were floxed and an FRT flanked neo cassette placed in intron 5. The neo cassette was removed by flp-mediated recombination, leaving exons 4 and 5 flanked by loxP sites. (J:156531)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Stk4^tm1.1Rjo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stk4 Mutation: 74 strains or lines available

References

• Original: J:156531 Lu L, et al., Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1437-42
• All: 35 reference(s)