Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 8, Klaus Rajewsky |
MGI ID: |
MGI:4430550 |
Synonyms: |
MEk1DD, R26StopFLMEK1DD, R26Stop flox MEK1DD, R26Stop-flox-MEK1DD, ROSAMEK1* |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky page
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Germline Transmission: |
Earliest citation of germline transmission:
J:157297
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
rat |
Map2k1 (170851) |
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Mutation details: A targeting vector designed with (from 5' to 3') a splice acceptor site, a loxP-flanked Neo-STOP cassette, a cDNA sequence encoding rat MEK1DD (a mutant form of MAPKK1 rendered constitutively active by two serine to aspartic acid substitutions (S218D/S222D) within the catalytic domain], an FRT-flanked internal ribosomal entry site-enhanced green fluorescent protein cassette (IRES-EGFP), and bovine polyadenylation signal. This transgene construct was inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus.
(J:157297)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:157297 Srinivasan L, et al., PI3 kinase signals BCR-dependent mature B cell survival. Cell. 2009 Oct 30;139(3):573-86 |
All: |
32 reference(s) |
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