Esr1^tm1.1Scma
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1.1Scma
• Name: estrogen receptor 1 (alpha); targeted mutation 1.1, Stavros C Manolagas
• MGI ID: MGI:4430564
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1.1Scma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156947
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was floxed and an frt flanked neo cassette was inserted via homologous recombination. Flp mediated recombination then removed the neo cassette. (J:156947)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 68 strains or lines available

References

• Original: J:156947 Martin-Millan M, et al., The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol. 2010 Feb;24(2):323-34
• All: 4 reference(s)