Trp53^tm6Xu
Targeted Allele Detail

Summary

• Symbol: Trp53^tm6Xu
• Name: transformation related protein 53; targeted mutation 6, Yang Xu
• MGI ID: MGI:4430743
• Synonyms: p53^Gln25Ser26, p53^QS-Neo
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm6Xu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157041
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Leucine codon 25 (TTA) in exon 2 was changed to glutamine and tryptophan codon 26 (TTG) to serine (p.L25Q, p.W26S) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 4. The neo cassette was removed through subsequent Cre-mediated recombination. (J:157299)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:157299 Chao C, et al., p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J. 2000 Sep 15;19(18):4967-75
• All: 2 reference(s)