Tg(Emu-TXLNA)1Amjr
Transgene Detail

Summary

• Symbol: Tg(Emu-TXLNA)1Amjr
• Name: transgene insertion 1, Julian Ambrus Jr
• MGI ID: MGI:4430747
• Synonyms: IL-14alpha Tg, pEuSR-IL-14alpha
• Transgene: Tg(Emu-TXLNA)1Amjr Location: unknown Genetic Position: Chr18, Syntenic
• Alliance: Tg(Emu-TXLNA)1Amjr page

Transgene origin

• Strain of Origin: (C3H x C57BL/6J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Emu-TXLNA)1Amjr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TXLNA (200081)

  Txlna

  (MGI:105968)

• Mutation details: The pEmuSR-IL-14alpha transgene was designed with the Emu immunoglobulin heavy chain enhancer/SV40 promoter regions (from the pEmuSR vector) upstream of a hemagglutinin-tagged human IL-14alpha (TXLNA or taxilin alpha) cDNA sequence (human IL-14alpha is a cytokine encoded by the plus strand of the IL-14 gene using exons 3-10). FISH analysis showed positive immunofluorescence on chromosome 18. (J:117018)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:117018 Shen L, et al., Development of autoimmunity in IL-14alpha-transgenic mice. J Immunol. 2006 Oct 15;177(8):5676-86
• All: 5 reference(s)