F2r^tm2Cgh
Targeted Allele Detail

Summary

• Symbol: F2r^tm2Cgh
• Name: coagulation factor II thrombin receptor; targeted mutation 2, Shaun R Coughlin
• MGI ID: MGI:4430880
• Gene: F2r Location: Chr13:95738311-95754995 bp, - strand Genetic Position: Chr13, 50.21 cM
• Alliance: F2r^tm2Cgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157446
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The ATG and codons 2 to 4 of exon 1 were replaced with a lacZ-loxP-PGK-hygro cassette. This targeting event occurred in ES cells already carrying the F2rl1^tm2Cgh allele and in cis with this allele. (J:157446)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2r Mutation: 26 strains or lines available

Notes

This allele only occurs in conjunction with F2rl1^tm2Cgh.

References

• Original: J:157446 Camerer E, et al., Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010 Jan 19;18(1):25-38
• All: 2 reference(s)