Tg(Abpa-cre)1Cmal
Transgene Detail

Summary

• Symbol: Tg(Abpa-cre)1Cmal
• Name: transgene insertion 1, Charles M Allan
• MGI ID: MGI:4431035
• Synonyms: Abp.Cre
• Transgene: Tg(Abpa-cre)1Cmal Location: unknown
• Alliance: Tg(Abpa-cre)1Cmal page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Abpa-cre)1Cmal expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Shbg (24775)

  Shbg	(MGI:98295)

• Mutation details: The transgene construct contained a 3.4 kb fragment of the cre recombinase sequence dowstream of the 1.5 kb rat Abpa promoter. This was followed by the metallothionein I (MT-1) sequence with polyA signal. The purified, linearized construct was injected into fertilized B6D2F1 oocytes. 10 founders were obtained, with 9 showing testicular cre mRNA expression. One line was propagated. (J:157337)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Shbg (rat) Summary of all recombinase alleles driven by Shbg. Comparative matrix view of recombinase activities Alliance rat Shbg gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:157337 Lim P, et al., Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis. Endocrinology. 2009 Oct;150(10):4755-65
• All: 1 reference(s)