Ppp1r3b^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Ppp1r3b^tm1.1Arte
• Name: protein phosphatase 1, regulatory subunit 3B; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:4431078
• Synonyms: GL^Y284F
• Gene: Ppp1r3b Location: Chr8:35842893-35855293 bp, + strand Genetic Position: Chr8, 21.16 cM
• Alliance: Ppp1r3b^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157291
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: An A to T substitution within exon 2 results in the amino acid substitution of phenylalanine for tyrosine at position 284 (Y284F). This allele is critical for binding to phosphorylase a. An frt flanked neo cassette used for selection purposes was removed by flp mediated recombination leaving a single frt site upstream of exon 2. (J:157291)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r3b Mutation: 16 strains or lines available

References

• Original: J:157291 Kelsall IR, et al., Disruption of the allosteric phosphorylase a regulation of the hepatic glycogen-targeted protein phosphatase 1 improves glucose tolerance in vivo. Cell Signal. 2009 Jul;21(7):1123-34
• All: 2 reference(s)