Insl6^tm1Imad
Targeted Allele Detail

Summary

• Symbol: Insl6^tm1Imad
• Name: insulin-like 6; targeted mutation 1, Ibrahim M Adham
• MGI ID: MGI:4431170
• Gene: Insl6 Location: Chr19:29298754-29302718 bp, - strand Genetic Position: Chr19, 23.82 cM, cytoband C3
• Alliance: Insl6^tm1Imad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157348
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR in testis extracts. (J:157348)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insl6 Mutation: 9 strains or lines available

References

• Original: J:157348 Burnicka-Turek O, et al., Inactivation of insulin-like factor 6 disrupts the progression of spermatogenesis at late meiotic prophase. Endocrinology. 2009 Sep;150(9):4348-57
• All: 2 reference(s)