Ripk3^tm1Xidw
Targeted Allele Detail

Summary

• Symbol: Ripk3^tm1Xidw
• Name: receptor-interacting serine-threonine kinase 3; targeted mutation 1, Xiaodong Wang
• MGI ID: MGI:4431195
• Synonyms: Ripk3^-
• Gene: Ripk3 Location: Chr14:56022452-56026314 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Ripk3^tm1Xidw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157346
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were replaced with a loxP site flanked neomycin resistance gene cassette. The absence of protein exprerssion was confirmed by western blot analysis on saline- and cerulein-treated mouse embryonic fibroblasts. (J:157346)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk3 Mutation: 34 strains or lines available

References

• Original: J:157346 He S, et al., Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell. 2009 Jun 12;137(6):1100-11
• All: 31 reference(s)