Terf1^tm2.1Tdl
Targeted Allele Detail

Summary

• Symbol: Terf1^tm2.1Tdl
• Name: telomeric repeat binding factor 1; targeted mutation 2.1, Titia de Lange
• MGI ID: MGI:4431206
• Synonyms: TRF1^F
• Gene: Terf1 Location: Chr1:15875870-15914276 bp, + strand Genetic Position: Chr1, 4.88 cM, cytoband E3
• Alliance: Terf1^tm2.1Tdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157331
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Cre mediated recombination removed the neo cassette leaving exon 1 floxed. (J:157331)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Terf1 Mutation: 37 strains or lines available

References

• Original: J:157331 Sfeir A, et al., Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell. 2009 Jul 10;138(1):90-103
• All: 9 reference(s)