Plppr4^tm1Roni
Targeted Allele Detail

Summary

• Symbol: Plppr4^tm1Roni
• Name: phospholipid phosphatase related 4; targeted mutation 1, Robert Nitsch
• MGI ID: MGI:4431223
• Synonyms: PRG-1^-
• Gene: Plppr4 Location: Chr3:117112794-117154525 bp, - strand Genetic Position: Chr3, 50.57 cM
• Alliance: Plppr4^tm1Roni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157318
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence spanning part of exon 4 through exon 6 was replaced with a triple STOP sequence, IRES, lacZ gene, and neo cassette. Absence of protein expression was confirmed by western blot analysis on brain extracts. (J:157318)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plppr4 Mutation: 29 strains or lines available

References

• Original: J:157318 Trimbuch T, et al., Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell. 2009 Sep 18;138(6):1222-35
• All: 7 reference(s)