Tg(Eno2-Hmox1)2Main
Transgene Detail

Summary

• Symbol: Tg(Eno2-Hmox1)2Main
• Name: transgene insertion 2, Mahin D Maines
• MGI ID: MGI:4431225
• Synonyms: HO-1 Tg
• Transgene: Tg(Eno2-Hmox1)2Main Location: unknown
• Alliance: Tg(Eno2-Hmox1)2Main page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-Hmox1)2Main expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Hmox1 (24451)

  Hmox1

  (MGI:96163)

• Mutation details: A rat heme oxygenase (decycling) 1 cDNA (nucleotide -14 through the poly[A] tail) was placed downstream of a 1.8 kb genomic DNA fragment containing the rat neuron-specific enolase (enolase 2, gamma neuronal) promoter. Homozygous transgenic mice exhibit elevation of Hmox1 mRNA and protein expression and enzyme activity. The increase in mRNA is modest in brain (115% of control level) and robust in spleen (200% of control level); no significant change in Hmox1 mRNA expression is detected in liver, kidney or testis. In situ hybridization and immunohistologic analysis demonstrates elevated Hmox1 expression in various regions of the brain. (J:120240)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This is one of six founder lines whose generation is described, but which are not assigned line numbers, in J:120240.

References

• Original: J:120240 Maines MD, et al., Neuronal overexpression of heme oxygenase-1 correlates with an attenuated exploratory behavior and causes an increase in neuronal NADPH diaphorase staining. J Neurochem. 1998 May;70(5):2057-69
• All: 1 reference(s)