Gt(ROSA)26Sor^{tm1(RARA*)Clmd}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(RARA*)Clmd}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Cathy Mendelsohn
• MGI ID: MGI:4431227
• Synonyms: Gt(ROSA)RARa403, RaraDN^flox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(RARA*)Clmd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157254
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(RARA*)Clmd} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RARA (5914)

  Rara	(MGI:97856)

• Mutation details: A truncated human RARA terminating after amino acid 403 was targeted into the Rosa26 locus but remains unexpressed until a loxP flanked stop sequence is removed via Cre-mediated recombination. (J:157254)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 992 strains or lines available

References

• Original: J:157254 Rosselot C, et al., Non-cell-autonomous retinoid signaling is crucial for renal development. Development. 2010 Jan;137(2):283-92
• All: 16 reference(s)