Ephb2^tm3.1Jf
Targeted Allele Detail

Summary

• Symbol: Ephb2^tm3.1Jf
• Name: Eph receptor B2; targeted mutation 3.1, Jonas Frisen
• MGI ID: MGI:4431255
• Synonyms: Ephb2^K661R
• Gene: Ephb2 Location: Chr4:136374850-136563299 bp, - strand Genetic Position: Chr4, 69.0 cM, cytoband D-E
• Alliance: Ephb2^tm3.1Jf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157019
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: A single nucleotide change was introduced within exon 12, resulting in amino acid substitution K661R, and a floxed neomycin phosphotransferase cassette was inserted within intron 11 by homologous recombination. This change is expected to disrupt the kinase activity. The selection cassette has been removed by cre mediated recombination. (J:157019)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ephb2 Mutation: 68 strains or lines available

References

• Original: J:157019 Genander M, et al., Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell. 2009 Nov 13;139(4):679-92
• All: 4 reference(s)