Ephb2^tm4.1Jf
Targeted Allele Detail

Summary

• Symbol: Ephb2^tm4.1Jf
• Name: Eph receptor B2; targeted mutation 4.1, Jonas Frisen
• MGI ID: MGI:4431257
• Synonyms: EphB2^{K661RdeltaPDZ}, Ephb2^{K661R/deltaVEV}
• Gene: Ephb2 Location: Chr4:136374850-136563299 bp, - strand Genetic Position: Chr4, 69.0 cM, cytoband D-E
• Alliance: Ephb2^tm4.1Jf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157019
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion, Single point mutation
• Mutation details: A single nucleotide change was introduced within exon 12 resulting in an amino acid substitution K661R and codons 992-994 were deleted by homologous recombination. In addition a floxed neomycin phosphotransferase cassette was inserted in intron 11 and an FRT flanked hygro cassette was inserted within exon 17 by homologous recombination. The selection cassettes have been removed by flp and cre mediated recombination. (J:157019)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ephb2 Mutation: 68 strains or lines available

References

• Original: J:157019 Genander M, et al., Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell. 2009 Nov 13;139(4):679-92
• All: 5 reference(s)