Il4/Il13^tm1.1Lky
Targeted Allele Detail

Summary

• Symbol: Il4/Il13^tm1.1Lky
• Name: interleukin 4; targeted mutation 1.1, Richard M Locksley
• MGI ID: MGI:4431367
• Synonyms: 4-13^F, Il4-IL13^fl
• Gene: Il4 Location: Chr11:53503287-53509492 bp, - strand Genetic Position: Chr11, 31.97 cM
• Alliance: Il4/Il13^tm1.1Lky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157129
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A single targeting event was used to insert a floxed Bsd resistance cassette between exon 2 and 3 of Il13 and an frt flanked neo cassette with a 3' loxP site downstream of exon 4 of Il4 . Flp and cre mediated recombination removed the selection cassettes leaving the region between exon 3 of Il13 and exon 4 of Il4 floxed. (J:157129)

Generation of the Il4/Il13^tm1.1Lky allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il4 Mutation: 46 strains or lines available

References

• Original: J:157129 Voehringer D, et al., Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. BMC Biotechnol. 2009;9:69
• All: 17 reference(s)