Ruvbl1tm1a(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Ruvbl1tm1a(EUCOMM)Wtsi |
Name: |
RuvB-like AAA ATPase 1; targeted mutation 1a, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:4432034 |
Synonyms: |
Pontin- |
Gene: |
Ruvbl1 Location: Chr6:88442391-88474548 bp, + strand Genetic Position: Chr6, 39.51 cM
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Alliance: |
Ruvbl1tm1a(EUCOMM)Wtsi page
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IMPC: |
Ruvbl1 gene page |
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Mutant Cell Lines: |
EPD0089_2_A10, EPD0089_2_A11, EPD0089_2_B10, EPD0089_2_B11, EPD0089_2_C10, EPD0089_2_C11, EPD0089_2_C12, EPD0089_2_E11, EPD0089_2_F10, EPD0089_2_F11, EPD0089_2_F12, EPD0089_2_G10, EPD0089_2_G11, EPD0089_2_G12, EPD0089_2_H10, EPD0089_2_H11, EPD0089_2_H12 |
Germline Transmission: |
Earliest citation of germline transmission:
J:165965
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Parent Cell Line: |
JM8.F6 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready, Null/knockout, Reporter) |
Mutation: |
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Insertion
Vector: L1L2_gt0
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Mutation details: The L1L2_gt0 cassette was inserted at position 88449623 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 88450412. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:155845, J:173534)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010; |
All: |
7 reference(s) |
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