Arvcf^{tm1e(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Arvcf^{tm1e(EUCOMM)Wtsi}
• Name: armadillo repeat gene deleted in velocardiofacial syndrome; targeted mutation 1e, Wellcome Trust Sanger Institute
• MGI ID: MGI:4432634
• Gene: Arvcf Location: Chr16:18166046-18225826 bp, + strand Genetic Position: Chr16, 11.37 cM
• Alliance: Arvcf^{tm1e(EUCOMM)Wtsi} page
• IMPC: Arvcf gene page

Mutation origin

• Mutant Cell Lines: EPD0102_1_A05, EPD0102_1_C04, EPD0102_1_C05, EPD0102_1_C06, EPD0102_1_D04, EPD0102_1_D06, EPD0102_1_E05, EPD0102_1_G04
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 18214400 of Chromosome 16 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Arvcf Mutation: 84 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 6 reference(s)