Nxn^{tm1a(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Nxn^{tm1a(EUCOMM)Wtsi}
• Name: nucleoredoxin; targeted mutation 1a, Wellcome Trust Sanger Institute
• MGI ID: MGI:4432925
• Gene: Nxn Location: Chr11:76148052-76289967 bp, - strand Genetic Position: Chr11, 45.92 cM
• Alliance: Nxn^{tm1a(EUCOMM)Wtsi} page
• IMPC: Nxn gene page

Mutation origin

• Mutant Cell Lines: EPD0045_1_A10, EPD0045_1_A11, EPD0045_1_B11, EPD0045_1_C10, EPD0045_1_C11, EPD0045_1_C12, EPD0045_1_D11, EPD0045_1_D12, EPD0045_1_E10, EPD0045_1_E11, EPD0045_1_F11, EPD0045_1_G10, EPD0045_1_G11, EPD0045_1_G12, EPD0045_1_H11, EPD0045_1_H12
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 76168930 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 76169881. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534, J:313744)

Expression

In Mice Carrying this Mutation:	61 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 1 line available
• Carrying any Nxn Mutation: 502 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 8 reference(s)