Caprin2^{tm2a(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Caprin2^{tm2a(EUCOMM)Wtsi}
• Name: caprin family member 2; targeted mutation 2a, Wellcome Trust Sanger Institute
• MGI ID: MGI:4434168
• Synonyms: Caprin2^flox
• Gene: Caprin2 Location: Chr6:148743990-148797735 bp, - strand Genetic Position: Chr6, 78.62 cM
• Alliance: Caprin2^{tm2a(EUCOMM)Wtsi} page
• IMPC: Caprin2 gene page

Mutation origin

• Mutant Cell Lines: EPD0069_4_C02, EPD0069_4_C03, EPD0069_4_H03
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 148778960 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 148779938. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534, J:225905)

Expression

In Mice Carrying this Mutation:	64 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Caprin2 Mutation: 40 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Peters Anomaly in homozygous mice carrying Tg(Pax6-GFP/cre)1Rilm (J:225905)

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 5 reference(s)